Recently some new tests for herpes have become available which are both helpful and confusing. I would like to review the indications for testing after a brief review of herpes.
Type 1 Herpes Simples virus (HSV-1) is responsible for most oral herpes commonly known as
cold sores, but it can also cause genital ulcers.
Type 2 Herpes (HSV-2) is responsible for 85% of genital herpes. HSV-2 is
the most prevalent sexually transmitted disease (STD) in the United States. 45-60 million people, 1 out of 5 Americans, live with this infection. There are 1 million new cases each year. About 25% of the US population aged 25-45 years old has been exposed to HSV-2 compared to 90% of the population exposed to HSV-1.
Signs and symptoms vary. The classic finding is a cluster of tender
blisters which turn into shallow ulcers. The first episode is usually the most severe and may be associated with symptoms such as fever. A culture of these lesions is the gold standard to establish the diagnosis.
A variety of
triggers such as stress, fatigue, mechanical irritation, and menstruation can cause the symptoms to recur.
Recurrent symptoms are usually milder than the first episode, but the psychological impact of the disease can be severe. Depression and anxiety from fear of recurrent attacks or transmission to current or potential partners are not uncommon. The infection may be transmitted even when there are no symptoms. This is called
asymptomatic shedding which occurs in nearly all infected individuals. Condoms help protect against herpes but they are not 100% effective.
So what about testing ? HSV type specific serological (blood) tests are now available, however, the test is NOT recommended for routine screening in the general population. Who may be considered for the test? According to the
2003 California STD Controllers Guidelines, HSV-2 serology may be used in this group but mostly if it will impact behavior.
--Asymptomatic partners of HSV-2 positive patients.
--Diagnosis of atypical genital lesions.
--Screening of high risk behavior patients.
--Selected pregnant patients.
--Asymptomatic HIV positive patients.
As an aside for the docs, IgM testing is not recommended.
Treatment is available which can reduce the severity of the disease, the number of recurrences and the transmission risk to partners. However, there is no cure. Vaccine trials are underway.
Herpevac is one of the many under investigation.
Resources for patients with HSV:
National Herpes Hotline (916-361-8488),
American Herpes Foundation (201-342-4441),
American Social Health Association ( 919-361-8400), and
social web sites .
References:
2003 California STD Controllers Association Guidelines. Shedding in the absence of lesions. Wald A et al. N England Journal of Medicine. 2000;342:845-850.
Managing patients with genital herpes and their sexual partners. Patel, Rompalo. Infect Dis Clin Norht Am 2005;19(2):427-38, x.
Tracking the Hidden Epidemics, Herpes.
Dr. Huyen Cao, Director of International Cellular Immunology, California Department of Health Services.
Photo courtesy of:
Worried.