US6132762A - Transcutaneous application of marijuana - Google Patents

Transcutaneous application of marijuana Download PDF

Info

Publication number
US6132762A
US6132762A US09/073,111 US7311198A US6132762A US 6132762 A US6132762 A US 6132762A US 7311198 A US7311198 A US 7311198A US 6132762 A US6132762 A US 6132762A
Authority
US
United States
Prior art keywords
formulation
marijuana
animal
human
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US09/073,111
Inventor
Walter Cristobal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US09/073,111 priority Critical patent/US6132762A/en
Application granted granted Critical
Publication of US6132762A publication Critical patent/US6132762A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Definitions

  • the present invention relates to the transcutaneous treatment of pain, inflamation and arthritic conditions using marijuana.
  • Marijuana contains many compounds, the major psychoactive compound being ⁇ 1 -Tetrahydrocannabinol (THC), also known as ⁇ 9 -THC depending on the carbon numbering convention used (Mechoulam, R., Science, 168: 1159-1166, 1970). THC and other compounds in marijuana have been reported to have activities in addition to pyschoactivity. researchers have reported beneficial activities that cause analgesic, antiemetic, and antiglaucoma effects. However, researchers have not identified all of the compounds and functional groups responsible for these pharmacological effects.
  • THC Tetrahydrocannabinol
  • this agent When administered orally in a safflower oil carrier, this agent demonstrated antiinflammatory properties in adjuvant-induced polyarthritic rats.
  • the dose level for marked analgesic and antiinflammatory effects was on the order of one microgram of DMH-11C to one kg of body weight.
  • researchers working on DMH-11C purport a plan for developing parenteral formulations as well (Developing the Next Generation of Analgesic and Antiinflammatory Drugs, http://www.atlan.com/anlgesc2.htm, Apr. 23, 1998).
  • no one has yet to utilize topical administration of marijuana solutions, THC or agents with a cannabinoid-like structure for the treatment of inflammation or arthritis.
  • U.S. Pat. No. 5,389,375 entitled “Stable Suppository Formulations Effecting Bioavailability of ⁇ 9 -THC,” issued Feb. 14, 1995, to ElSohly, discloses a suppository formulation containing a ⁇ 9 -THC prodrug ester derivatives in a lipophilic, aprotic lipohilic, paraffin or triacyglyceride carrier base.
  • U.S. Pat. No. 5,508,037 entitled “Stable Suppository Formulations Effecting Bioavailability of ⁇ 9 -THC,” issued Apr. 16, 1996, to ElSohly, discloses a suppository formulation containing a ⁇ 9 -THC prodrug ester for the treatment of pain, spasticity, appetite, depression, anxiety, night vision, and migraine headaches.
  • U.S. Pat. No. 5,635,530 entitled “(3S-4S)- ⁇ 6 TETRAHYDROCANNABINOL-7-OIC ACIDS and Dervatives Thereof, Processors for Their Preparation and Pharmaceutical Compositions Containing Them,” issued Jun. 3, 1997, to Mechoulam, et al, discloses (3S-4S)- ⁇ 6 -tetrahydrocannabinol-7-oic acid derivatives that exhibit analgesic, antiinflamatory, antiemetic, antiglaucoma, leukocyte antiadhesion, and platelet adhesion factor activity.
  • the invention is a formulation comprising a therapeutically effective amount of marijuana and a pharmaceutically acceptable topical, transcutaneous carrier.
  • the carrier comprises at least one member selected from the group consisting of water, alcohol, aldehyde, ketone, carboxylic acid, mineral oil and dimethyl sulfoxide.
  • an alcohol carrier at least one hydroxyl group per molecule is present.
  • the carrier is an alcohol or other molecule, the carbon chain length, if the carrier contains carbon, is typically between approximately C 1 and C 24 .
  • a preferred embodiment of the invention uses isopropanol as the carrier.
  • the carrier comprises at least 1% of the formulation by weight.
  • the carrier may comprise guar gum, gelatin, carboxymethylcellulose, carrageenan, agar or the like to modify rate of delivery and other formulation properties.
  • the dried marijuana weight of the formulation is between approximately 0.01% by weight and 30% by weight and preferably between 0.1% by weight and 10% by weight.
  • a preferred embodiment of the invention uses a carrier comprising isopropanol, between approximately 5% by weight and 99% by weight and preferably between approximately 50% by weight and 80% by weight, and water, between approximately 1% by weight and 100% by weight and preferably between 5% by weight and 100% by weight.
  • the therapeutic formulation is made by providing and combining a therapeutically effective amount of marijuana with a pharmaceutically acceptable topical, transcutaneous carrier.
  • Initial processing of the marijuana may be accomplished by drying, soaking, crushing, cutting, grinding, and chopping.
  • This is combined with a carrier comprising water, alcohol, aldehyde, ketone, carboxylic acid, mineral oil or dimethyl sulfoxide.
  • the carrier and marijuana can be combined by mixing, blending, steeping, soaking, boiling and the like.
  • the formulation serves as part of method of treating pain, inflammation, or arthritis comprising transcutaneously applying the formulation to a human or animal body part.
  • the invention aims to treat both human and animal pain, inflammation, arthritis, rheumatoid arthritis, and ailments causing similar bodily distress.
  • a primary object of the present invention is to relieve pain through the topical, transcutaneous application of a marijuana formulation.
  • a primary advantage of the present invention is that oral, intravenous, rectal or subcutaneous administration of the therapeutic product is avoided.
  • a further advantage of the present invention is that the marijuana carrier enhances availability of the active compounds.
  • Another advantage of the present invention is that the carrier controls transcutaneous absorption of the active marijuana compounds.
  • the present invention is directed to a formulation comprising marijuana and a carrier; a method of making or preparing this formulation; and a method of transcutaneously using this formulation to treat pain, inflammation, and arthritis.
  • the formulation comprises marijuana and a carrier.
  • the marijuana is added to the carrier as described in the method of preparation.
  • the carrier serves two purposes. The first purpose is as a solvent to extract and solubilize the active compounds in marijuana. The second purpose is to control the rate of adsorption through the skin. The latter purpose is discussed in detail below.
  • the carrier comprises water, alcohol, or other hydrophilic and hydrophobic solvents.
  • the weight percentages or volume of carrier and marijuana depend on a variety of factors related to the marijuana and its method of preparation.
  • the water ranges between approximately 5% by weight and 100% by weight and preferably between approximately 20% by weight and 100% by weight.
  • the alcohol ranges between approximately 5% by weight and 100% by weight, preferably between approximately 10% by weight and 95% by weight.
  • the carrier may comprise combinations of more than one type of carrier, e.g., a combination of alcohol and water.
  • the average carbon chain length of the alcohol preferably falls between approxmately C1 and C24. Alcohols with multiple carbon chains may also be used. A preferred embodiment of the invention uses short carbon chain alcohols, preferably from C2 to C12.
  • the group utilized may be either a primary, secondary, or tertiary alcohol.
  • the groups may appear as primary, secondary, or tertiary alcohols.
  • a preferred embodiment of the invention uses C2 to C12 alcohols having from one to three hydroxyl groups.
  • solvents include Dimethylsulfoxide (DMSO), polyethylene glycol, polypropylene glycol, ethanol, propanol, isopropanol, glycerin, and mineral oil.
  • DMSO Dimethylsulfoxide
  • all solvents may be combined with gel forming compounds such as guar gum, gelatin, carboxymethylcellulose, carrageenan, and agar to produce a lotion or cream for topical administration.
  • gel forming compounds such as guar gum, gelatin, carboxymethylcellulose, carrageenan, and agar.
  • Most of these compounds form gels through hydrogen bonding, thus, the use of polar protic solvents is preferable, e.g., isopropanol.
  • the method of preparing the formulation comprises mixing marijuana with a carrier.
  • concentration of active constituents in marijuana, as with all plants, varies with respect to genetic characteristics, growing and storage conditions.
  • the steps performed in preparing the marijuana, and marijuana and carrier formulation are tailored to the nature and quality of the marijuana used.
  • a basic first step entails preparation of the plant material.
  • the whole plant may be used for preparing the formulation.
  • the marijuana plant leaves may be separated from the plant stems and seeds; a preprepared extract of the plant's active ingredients; or synthesized marijuana; or active ingredients; or a combination thereof may be used.
  • processing steps such as drying and soaking may be followed by mechanical disruption of the plant material.
  • dried plant material is ground, cut or crushed to produce small flakes or particles of plant matter whereas soaked plant material is placed in a blender or other processor to disrupt the plant structure.
  • Mechanical disruption processes increase the surface area of the plant material and enhance extraction of the active compounds contained within the marijuana plant.
  • the nature of the marijuana preparation step also affects various subsequent steps. For instance, if the carrier is water, then either drying or soaking in water is an appropriate marijuana preparation step. However, if the carrier possesses hydrophobic qualities, then a drying step is preferably utilized to diminish the plant material's water content before further processing.
  • the entire mixture is preferably heated or agitated, however, heating and agitation are not necessary steps. Heating helps to disrupt the plant cell structure, release the active compounds from with the plant cells, and reduce the processing time. Heating also helps to solubilize the active compounds in marijuana. If the mixture is heated, heating occurs at temperatures from approximately 20° C. to 400° C. and preferably from approximately 20° C. to 110° C. The duration of the heating step is from between approximately minutes to days and preferably from between approximately 5 minutes and 1 day.
  • Agitation helps to disrupt plant cell structure and increase mass transfer between the plant and the carrier solution.
  • Various forms of agitation are useful ranging from gentle agitation by rolling or shaken to vigorous agitation, e.g., with an impeller blade.
  • a higher energy input to the mixture typically results in better disruption and enhanced mass transfer.
  • the energy input is also a function of agitation time. Typical agitation times vary preferably from between approximately seconds and days and preferably from between approximately 5 seconds and 1 hour.
  • the marijuana formulation provides for various therapeutic effects including the alleviation of pain, inflammation, and distress associated with arthritis.
  • the method of treatment includes primarily topical administration to the desired body part for transcutaneous absorption of the active compounds.
  • the temperature of the formulation may be adjusted to achieve the desired therapeutic effects. For instance, the formulation may be applied directly with no heating. Alternatively, the formulation may be heated to a temperature between approximately 20° C. and 80° C., and preferably between approximately 25° C. and 65° C., and applied directly to the skin or, the patient may soak the targeted body part in the formulation. Treatment times range from between approximately minutes and hours and preferably between approximately 1 minute and 30 minutes. Altematively, the formulation may be applied to the patient at room temperature and then the treated area may be heated by a heating pad, water bottle or the like. The temperature and treatment times are approximately the same as those given above.
  • the invention also provides for application of the formulation combined with cold treatment of the treated area. For instance, a patient may soak in a whirlpool filled with a cold formulation. Soaking times vary from between approximately minutes to hours and preferably between approximately 1 minutes and 1 hour. Use of the formulation at temperatures between approximately -40° C. and 20° C. and preferably between approximately -10° C. and 10° C. may provide therapeutic benefits in addition to cold treatment.
  • Covering the treated area may also increase efficacy of the formulation. Absorption of many topically applied drugs are enhanced by covering the treated skin with an impermeable plastic sheet or film that hinders evaporation or drug decomposition.
  • the impermeable barrier causes the keratin layer to soften and diminish resistance absorption, thereby facilitating absorption of the drug (Annual Review of Medicine, Vol. 33, Ch. 18, 1982, "The Principles of Drug Therapy in Skin Disorders," R. C. Heading, p. 475,476).
  • the formulation delivery mechanism can incorporate a barrier layer made of plastic or film. Altematively, covering the treated area with cellophane wrap or a similar material can provide similar beneficial increases in formulation efficacy. Treatment methods using a combination of covered and uncovered regimens are within the scope of the present invention.
  • the formulation may be in the form of a gel.
  • the properties of the gel may be adjusted to control the extraction of active compounds from the marijuana plant material and the rate of transdermal absorption.
  • the transdermal rate of absorption of a drug is increased or decreased depending on the carrier and method of application.
  • Typical carrier solvents for topically administered drugs for transdermal delivery include propylene glycol, glycerin, mineral oil, polyethylene glycol, Dimethylsulfoxide (DMSO) or alcohol. Judicious choice of the carrier is necessary, however, when using a gel formulation. Since many gels are based on hydrogen bonding, the gel may disrupt in the presence of a hydrophilic solvent and negate the intended therapeutic effects.
  • the gel formulation may be placed into a suitable delivery mechanism, e.g., a patch.
  • a delivery mechanism containing the formulation is then placed in the vicinity of the area to be treated.
  • placement of the delivery mechanism in another area e.g., along an upstream blood or lymph supply route, may provide beneficial treatment as well.
  • all formulations, including the gel formulation may be, as described above, heated or cooled to achieve the desired therapeutic effect.
  • One ounce of unprocessed marijuana was prepared together with 120 ounces of a solution containing 70% wt. isopropanol and 30% wt. water.
  • the marijuana and isopropanol/water solution was then mixed and let to steep at room temperature, unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
  • One half ounce of unprocessed marijuana was prepared together with 12 ounces of a solution containing 70% wt. isopropanol and 30% wt. water.
  • the marijuana and isopropanol/water solution was then mixed and let to steep at room temperature, unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
  • One ounce of unprocessed marijuana was prepared together with 120 ounces of water.
  • the marijuana and water solution was then mixed and let to steep at 65° F., unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
  • One half ounce of unprocessed marijuana was prepared together with 12 ounces of water.
  • the marijuana and water solution was then mixed and let to steep at 65° F., unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.

Abstract

A transcutaneous therapeutic formulation comprising marijuana and a carrier for the treatment of pain, inflammation, arthritis and related disorders in humans and animals.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of the filing of U.S. Provisional patent application Ser. No. 60/045,620, entitled Pain Reliever Solution, filed on May 5, 1997 now abandoned, and the specification thereof is incorporated herein by reference.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the transcutaneous treatment of pain, inflamation and arthritic conditions using marijuana.
2. Background Art
Marijuana contains many compounds, the major psychoactive compound being Δ1 -Tetrahydrocannabinol (THC), also known as Δ9 -THC depending on the carbon numbering convention used (Mechoulam, R., Science, 168: 1159-1166, 1970). THC and other compounds in marijuana have been reported to have activities in addition to pyschoactivity. Researchers have reported beneficial activities that cause analgesic, antiemetic, and antiglaucoma effects. However, researchers have not identified all of the compounds and functional groups responsible for these pharmacological effects.
The social stigma and unwanted side-effects associated with recreational marijuana use motivated the search for antipsychoactive THC derivatives and analogs. Since the mid-1970s, scientists have examined various forms of THC, particularly Δ1 -THC metabolites that lack psychoactive properties. For example, researchers have focused recently on dimethylheptyl-THC-11 oic acid (DMH-11C) and its use as a nonpsychoactive antiinflamatory agent (Zurier, R. B., Rosesetti, R. G., Lane, J. H., Goldberg, J. M., Hunter, S. A., Burnstein, S. H., Arthritis & Rheumatism, 41:163-170, 1998). When administered orally in a safflower oil carrier, this agent demonstrated antiinflammatory properties in adjuvant-induced polyarthritic rats. The dose level for marked analgesic and antiinflammatory effects was on the order of one microgram of DMH-11C to one kg of body weight. Researchers working on DMH-11C purport a plan for developing parenteral formulations as well (Developing the Next Generation of Analgesic and Antiinflammatory Drugs, http://www.atlan.com/anlgesc2.htm, Apr. 23, 1998). However, no one has yet to utilize topical administration of marijuana solutions, THC or agents with a cannabinoid-like structure for the treatment of inflammation or arthritis.
The following patents disclose information in related fields; however, none of these patents disclose the use of transcutaneous or transdermal application of marijuana mixtures or solutions for treating pain, inflammation or arthritic conditions.
U.S. Pat. No. 4,189,491, entitled "Tetrahydrocannabinal in a Method of Treating Glaucoma," issued Feb. 19, 1980, to Shapiro and Cuendet, discloses oral administration of a sub-psychotropic dose of THC to reduce intraocular pressure in glaucoma sufferers.
U.S. Pat. No. 4,476,140, entitled "Composition and Method for Treatment of Glaucoma," issued Oct. 9, 1984, to Sears and Caprioli, discloses a topical treatment to the eye for reducing intraocular pressure using polyoxygenated Labdanes as the active ingredient.
U.S. Pat. No. 4,847,290, entitled "Delta 1-THC-7-OIC Acid and Analgesic and Anti-inflammatory Agents," issued Jul. 11, 1989, to Bumstein, discloses a THC template structure with antiinflammatory and analgesic therapeutic properties. The agent, when administered orally, is nonulcerogenic.
U.S. Pat. No. 4,876,276, entitled "(3S-4S)-7-HYDROXY-Δ6 -TETRAHYDROCANNABINOLS," issued Oct. 24, 1989, to Mechoulam, et al., discloses (3S-4S)-7-hydroxy-Δ6 -tetrahydrocannabinol homologes and derivatives which have analgetic, antiemectic, and antiglaucoma effect when administered orally, by injection, topically for intraocular use or by suppositories.
U.S. Pat. No. 5,389,375, entitled "Stable Suppository Formulations Effecting Bioavailability of Δ9 -THC," issued Feb. 14, 1995, to ElSohly, discloses a suppository formulation containing a Δ9 -THC prodrug ester derivatives in a lipophilic, aprotic lipohilic, paraffin or triacyglyceride carrier base.
U.S. Pat. No. 5,508,037, entitled "Stable Suppository Formulations Effecting Bioavailability of Δ9 -THC," issued Apr. 16, 1996, to ElSohly, discloses a suppository formulation containing a Δ9 -THC prodrug ester for the treatment of pain, spasticity, appetite, depression, anxiety, night vision, and migraine headaches.
U.S. Pat. No. 5,635,530, entitled "(3S-4S)-Δ6 TETRAHYDROCANNABINOL-7-OIC ACIDS and Dervatives Thereof, Processors for Their Preparation and Pharmaceutical Compositions Containing Them," issued Jun. 3, 1997, to Mechoulam, et al, discloses (3S-4S)-Δ6 -tetrahydrocannabinol-7-oic acid derivatives that exhibit analgesic, antiinflamatory, antiemetic, antiglaucoma, leukocyte antiadhesion, and platelet adhesion factor activity.
None of the aforementioned references disclose a topical, transcutaneous treatment derived from the marijuana plant with analgesic, antiinflammatory, antirheumatic, leukocyte antiadhesion or other activities. Only topical ocular, oral, rectal, intravenous and other non-topical treatments are disclosed.
SUMMARY OF THE INVENTION (DISCLOSURE OF THE INVENTION)
The invention is a formulation comprising a therapeutically effective amount of marijuana and a pharmaceutically acceptable topical, transcutaneous carrier. The carrier comprises at least one member selected from the group consisting of water, alcohol, aldehyde, ketone, carboxylic acid, mineral oil and dimethyl sulfoxide. For an alcohol carrier at least one hydroxyl group per molecule is present. Whether the carrier is an alcohol or other molecule, the carbon chain length, if the carrier contains carbon, is typically between approximately C1 and C24. A preferred embodiment of the invention uses isopropanol as the carrier. In general, the carrier comprises at least 1% of the formulation by weight. However, the carrier may comprise guar gum, gelatin, carboxymethylcellulose, carrageenan, agar or the like to modify rate of delivery and other formulation properties.
The dried marijuana weight of the formulation is between approximately 0.01% by weight and 30% by weight and preferably between 0.1% by weight and 10% by weight. A preferred embodiment of the invention uses a carrier comprising isopropanol, between approximately 5% by weight and 99% by weight and preferably between approximately 50% by weight and 80% by weight, and water, between approximately 1% by weight and 100% by weight and preferably between 5% by weight and 100% by weight.
The therapeutic formulation is made by providing and combining a therapeutically effective amount of marijuana with a pharmaceutically acceptable topical, transcutaneous carrier. Initial processing of the marijuana may be accomplished by drying, soaking, crushing, cutting, grinding, and chopping. This is combined with a carrier comprising water, alcohol, aldehyde, ketone, carboxylic acid, mineral oil or dimethyl sulfoxide. The carrier and marijuana can be combined by mixing, blending, steeping, soaking, boiling and the like.
The formulation serves as part of method of treating pain, inflammation, or arthritis comprising transcutaneously applying the formulation to a human or animal body part. The invention aims to treat both human and animal pain, inflammation, arthritis, rheumatoid arthritis, and ailments causing similar bodily distress.
A primary object of the present invention is to relieve pain through the topical, transcutaneous application of a marijuana formulation.
A primary advantage of the present invention is that oral, intravenous, rectal or subcutaneous administration of the therapeutic product is avoided.
A further advantage of the present invention is that the marijuana carrier enhances availability of the active compounds.
Another advantage of the present invention is that the carrier controls transcutaneous absorption of the active marijuana compounds.
Other objects, advantages and novel features, and further scope of applicability of the present invention will be set forth in part in the detailed description to follow and in part will become apparent to those skilled in the art upon examination of the following, or may be learned by practice of the invention. The objects and advantages of the invention may be realized and attained by means of the instrumentalities and combinations particularly pointed out in the appended claims.
DESCRIPTION OF THE PREFERRED EMBODIMENTS (BEST MODES FOR CARRYING OUT THE INVENTION)
The present invention is directed to a formulation comprising marijuana and a carrier; a method of making or preparing this formulation; and a method of transcutaneously using this formulation to treat pain, inflammation, and arthritis.
The formulation comprises marijuana and a carrier. The marijuana is added to the carrier as described in the method of preparation. The carrier serves two purposes. The first purpose is as a solvent to extract and solubilize the active compounds in marijuana. The second purpose is to control the rate of adsorption through the skin. The latter purpose is discussed in detail below.
For the extraction and solubilization of active marijuana compounds, the carrier comprises water, alcohol, or other hydrophilic and hydrophobic solvents. The weight percentages or volume of carrier and marijuana depend on a variety of factors related to the marijuana and its method of preparation. For a water carrier, the water ranges between approximately 5% by weight and 100% by weight and preferably between approximately 20% by weight and 100% by weight. For an alcohol carrier, the alcohol ranges between approximately 5% by weight and 100% by weight, preferably between approximately 10% by weight and 95% by weight. In addition, the carrier may comprise combinations of more than one type of carrier, e.g., a combination of alcohol and water.
For carriers comprising alcohols, the average carbon chain length of the alcohol preferably falls between approxmately C1 and C24. Alcohols with multiple carbon chains may also be used. A preferred embodiment of the invention uses short carbon chain alcohols, preferably from C2 to C12.
For alcohols having only one hydroxyl group, the group utilized may be either a primary, secondary, or tertiary alcohol. For alcohols having more than one hydroxyl group, the groups may appear as primary, secondary, or tertiary alcohols. A preferred embodiment of the invention uses C2 to C12 alcohols having from one to three hydroxyl groups.
In general, appropriate solvents include Dimethylsulfoxide (DMSO), polyethylene glycol, polypropylene glycol, ethanol, propanol, isopropanol, glycerin, and mineral oil. In addition, all solvents may be combined with gel forming compounds such as guar gum, gelatin, carboxymethylcellulose, carrageenan, and agar to produce a lotion or cream for topical administration. Most of these compounds form gels through hydrogen bonding, thus, the use of polar protic solvents is preferable, e.g., isopropanol.
The method of preparing the formulation comprises mixing marijuana with a carrier. The concentration of active constituents in marijuana, as with all plants, varies with respect to genetic characteristics, growing and storage conditions. Thus, the steps performed in preparing the marijuana, and marijuana and carrier formulation, are tailored to the nature and quality of the marijuana used.
A basic first step entails preparation of the plant material. The whole plant may be used for preparing the formulation. Altematively, the marijuana plant leaves may be separated from the plant stems and seeds; a preprepared extract of the plant's active ingredients; or synthesized marijuana; or active ingredients; or a combination thereof may be used.
For plant material, processing steps such as drying and soaking may be followed by mechanical disruption of the plant material. Typically, dried plant material is ground, cut or crushed to produce small flakes or particles of plant matter whereas soaked plant material is placed in a blender or other processor to disrupt the plant structure. Mechanical disruption processes increase the surface area of the plant material and enhance extraction of the active compounds contained within the marijuana plant. The nature of the marijuana preparation step also affects various subsequent steps. For instance, if the carrier is water, then either drying or soaking in water is an appropriate marijuana preparation step. However, if the carrier possesses hydrophobic qualities, then a drying step is preferably utilized to diminish the plant material's water content before further processing.
Once the plant material is prepared and mixed with the carrier, the entire mixture is preferably heated or agitated, however, heating and agitation are not necessary steps. Heating helps to disrupt the plant cell structure, release the active compounds from with the plant cells, and reduce the processing time. Heating also helps to solubilize the active compounds in marijuana. If the mixture is heated, heating occurs at temperatures from approximately 20° C. to 400° C. and preferably from approximately 20° C. to 110° C. The duration of the heating step is from between approximately minutes to days and preferably from between approximately 5 minutes and 1 day.
Agitation helps to disrupt plant cell structure and increase mass transfer between the plant and the carrier solution. Various forms of agitation are useful ranging from gentle agitation by rolling or shaken to vigorous agitation, e.g., with an impeller blade. A higher energy input to the mixture typically results in better disruption and enhanced mass transfer. The energy input is also a function of agitation time. Typical agitation times vary preferably from between approximately seconds and days and preferably from between approximately 5 seconds and 1 hour.
The marijuana formulation provides for various therapeutic effects including the alleviation of pain, inflammation, and distress associated with arthritis. The method of treatment includes primarily topical administration to the desired body part for transcutaneous absorption of the active compounds. The temperature of the formulation may be adjusted to achieve the desired therapeutic effects. For instance, the formulation may be applied directly with no heating. Alternatively, the formulation may be heated to a temperature between approximately 20° C. and 80° C., and preferably between approximately 25° C. and 65° C., and applied directly to the skin or, the patient may soak the targeted body part in the formulation. Treatment times range from between approximately minutes and hours and preferably between approximately 1 minute and 30 minutes. Altematively, the formulation may be applied to the patient at room temperature and then the treated area may be heated by a heating pad, water bottle or the like. The temperature and treatment times are approximately the same as those given above.
The invention also provides for application of the formulation combined with cold treatment of the treated area. For instance, a patient may soak in a whirlpool filled with a cold formulation. Soaking times vary from between approximately minutes to hours and preferably between approximately 1 minutes and 1 hour. Use of the formulation at temperatures between approximately -40° C. and 20° C. and preferably between approximately -10° C. and 10° C. may provide therapeutic benefits in addition to cold treatment.
Covering the treated area may also increase efficacy of the formulation. Absorption of many topically applied drugs are enhanced by covering the treated skin with an impermeable plastic sheet or film that hinders evaporation or drug decomposition. The impermeable barrier causes the keratin layer to soften and diminish resistance absorption, thereby facilitating absorption of the drug (Annual Review of Medicine, Vol. 33, Ch. 18, 1982, "The Principles of Drug Therapy in Skin Disorders," R. C. Heading, p. 475,476). The formulation delivery mechanism can incorporate a barrier layer made of plastic or film. Altematively, covering the treated area with cellophane wrap or a similar material can provide similar beneficial increases in formulation efficacy. Treatment methods using a combination of covered and uncovered regimens are within the scope of the present invention.
As discussed above, the formulation may be in the form of a gel. The properties of the gel may be adjusted to control the extraction of active compounds from the marijuana plant material and the rate of transdermal absorption. In general, the transdermal rate of absorption of a drug is increased or decreased depending on the carrier and method of application. Typical carrier solvents for topically administered drugs for transdermal delivery include propylene glycol, glycerin, mineral oil, polyethylene glycol, Dimethylsulfoxide (DMSO) or alcohol. Judicious choice of the carrier is necessary, however, when using a gel formulation. Since many gels are based on hydrogen bonding, the gel may disrupt in the presence of a hydrophilic solvent and negate the intended therapeutic effects.
The gel formulation, as with all formulations covered by this invention, may be placed into a suitable delivery mechanism, e.g., a patch. A delivery mechanism containing the formulation is then placed in the vicinity of the area to be treated. Alternatively, placement of the delivery mechanism in another area, e.g., along an upstream blood or lymph supply route, may provide beneficial treatment as well. Whether applied via a delivery mechanism or directly to the skin, all formulations, including the gel formulation, may be, as described above, heated or cooled to achieve the desired therapeutic effect.
EXAMPLES
Twenty patients with aliments including arthritis, tennis elbow, neck and other joint pain were treated with the formulation of the present invention in a blind study; they were not informed of the composition. Patients were advised to either topically administer the formulation or soak the troubled body area (e.g., arthritic hands) in the given formulation for a period of 10 to 30 minutes. For the first week, patients used the formulation on a daily basis; thereafter, once per week. Patients using the marijuana formulation reported a marked and nearly immediate decrease in pain and inflammation and an increase in joint mobility, some with only one treatment.
The solutions provided to these patients were prepared as follows:
Example I
One ounce of unprocessed marijuana was prepared together with 120 ounces of a solution containing 70% wt. isopropanol and 30% wt. water. The marijuana and isopropanol/water solution was then mixed and let to steep at room temperature, unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
Example II
One half ounce of unprocessed marijuana was prepared together with 12 ounces of a solution containing 70% wt. isopropanol and 30% wt. water. The marijuana and isopropanol/water solution was then mixed and let to steep at room temperature, unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
Example III
One ounce of unprocessed marijuana was prepared together with 120 ounces of water. The marijuana and water solution was then mixed and let to steep at 65° F., unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
Example IV
One half ounce of unprocessed marijuana was prepared together with 12 ounces of water. The marijuana and water solution was then mixed and let to steep at 65° F., unagitated for at least one hour. After steeping, the plant material was strained from the mixture using cotton cloth. Finally, the mixture was applied to a patient's skin using a clean cotton cloth.
The preceding examples can be repeated with similar success by substituting the generically or specifically described reactants, weight percentages, and/or operating conditions of this invention for those used in the preceding examples.
Although the invention has been described in detail with particular reference to these preferred embodiments, other embodiments can achieve the same results. Variations and modifications of the present invention will be obvious to those skilled in the art and it is intended to cover in the appended claims all such modifications and equivalents. The entire disclosures of all references, applications, patents, and publications cited above are hereby incorporated by reference.

Claims (12)

What is claimed is:
1. A method of treating joint pain, muscle pain, or arthritis comprising transcutaneously applying a formulation to a human or animal by way of a patch or cloth, the formulation comprising:
a therapeutically effective amount of an active marijuana compound extracted from the marijuana plant; and
a transcutaneous carrier selected from the group consisting of water, short carbon chain alcohols, dimethysulfoxide, polyethylene glycol, polypropylene glycol, glycerin, mineral oil and mixtures thereof.
2. The method of claim 1 further comprising the step of applying heat to the human or animal wherein applying heat comprises a member selected from the group consisting of applying heat to a treated area during application of the formulation and applying heat to a treated area after application of the formulation.
3. The method of claim 1 further comprising the step of withdrawing heat from the human or animal wherein withdrawing heat comprises a member selected from the group consisting of withdrawing heat from a treated area during application of the formulation and withdrawing heat from a treated area after application of the formulation.
4. The method of claim 1 further comprising the step of partially covering the human or animal with an impermeable barrier wherein the impermeable barrier comprises a member selected from the group consisting of a patch comprising an impermeable barrier and an impermeable film.
5. The method of claim 4 wherein the impermeable barrier comprises plastic.
6. The method of claim 1 wherein the formulation comprises a gel.
7. The method of claim 6 wherein the gel comprises at least one member selected from the group consisting of guar gum, gelatin, carboxymethylsellulose, carrageenan and agar.
8. The method of claim 1 further comprising the step of heating the formulation.
9. The method of claim 1 further comprising the step of cooling the formulation.
10. A method of treating joint pain, muscle pain, or arthritis comprising transcutaneously applying a formulation to a human or animal by way of soaking a targeted body part of the human or animal in the formulation, the formulation comprising:
a therapeutically effective amount of an active marijuana compound extracted from the marijuana plant; and
a transcutaneous carrier selected from the group consisting of water, short carbon chain alcohols, dimethylsulfoxide, polyethylene glycol, polypropylene glycol, glycerin, mineral oil and mixtures thereof.
11. The method of claim 10 further comprising the step of heating the formulation.
12. The method of claim 10 further comprising the step of cooling the formulation.
US09/073,111 1997-05-05 1998-05-05 Transcutaneous application of marijuana Expired - Lifetime US6132762A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US09/073,111 US6132762A (en) 1997-05-05 1998-05-05 Transcutaneous application of marijuana

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4562097P 1997-05-05 1997-05-05
US09/073,111 US6132762A (en) 1997-05-05 1998-05-05 Transcutaneous application of marijuana

Publications (1)

Publication Number Publication Date
US6132762A true US6132762A (en) 2000-10-17

Family

ID=26723009

Family Applications (1)

Application Number Title Priority Date Filing Date
US09/073,111 Expired - Lifetime US6132762A (en) 1997-05-05 1998-05-05 Transcutaneous application of marijuana

Country Status (1)

Country Link
US (1) US6132762A (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111377A1 (en) * 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
EP1329265A2 (en) * 2002-01-16 2003-07-23 Giuliano Silvestri Method and device for separating toxic components in plant parts and preparations produced thereby
DE10323497A1 (en) * 2003-02-26 2004-09-23 Musch, Stephan, Dr.med. Well tolerated liquid herbal preparation for reducing and/or adjusting intraocular pressure, containing plant extract(s) having dehydrating, blood purifying, hypotensive and/or spasmolytic action
US20050266061A1 (en) * 2000-12-22 2005-12-01 Stinchcomb Audra L Transdermal delivery of cannabinoids
US20060147510A1 (en) * 2001-10-25 2006-07-06 Endo Pharmaceuticals, Inc. Method for treating non-neuropathic pain
US20080312583A1 (en) * 2007-06-12 2008-12-18 Oronsky Bryan T Topical composition for treating pain
US20090036523A1 (en) * 2007-07-30 2009-02-05 Alltranz Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
US20090130182A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical compositions for treating pain
US20090247619A1 (en) * 2008-03-06 2009-10-01 University Of Kentucky Cannabinoid-Containing Compositions and Methods for Their Use
US20100012118A1 (en) * 2008-07-19 2010-01-21 Markus Storz Medicament dosage for inhaler
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
WO2010126501A1 (en) * 2009-04-29 2010-11-04 University Of Kentucky Research Foundation Cannabinoid-containing compositions and methods for their use
EP2263667A2 (en) 2005-06-16 2010-12-22 Euro-Celtique S.A. Compositions comprising crystalline trans-(+/-)-delta-9-tetrahydrocannabinol
US20110038915A1 (en) * 2009-08-14 2011-02-17 Eduardo Jose Gonzalez Chewing Gum Formula for Enhancing Psycho-Spirituality
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US9375417B2 (en) 2014-12-04 2016-06-28 Mary's Medicinals LLC Transdermal cannabinoid formulations
US9936650B2 (en) 2014-09-09 2018-04-10 Podgrow, LLC Secure and externally controllable growing enclosure
US10028904B2 (en) 2014-12-04 2018-07-24 Wisconsin Alumni Research Foundation Transdermal cannabinoid formulations
WO2019016814A1 (en) 2017-07-20 2019-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical film compositions for delivery of lipophilic compounds into and/or across the skin
US10456357B2 (en) * 2016-07-28 2019-10-29 Allen Greenspoon Orally administrable formulation
US11147777B1 (en) 2017-06-16 2021-10-19 Charlotte's Web, Inc. Methods and formulations for efficacious pain relief by transdermal delivery of cannabidiol

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189491A (en) * 1976-12-16 1980-02-19 Cuendet Jean Francois Tetrahydrocannabinol in a method of treating glaucoma
US4343798A (en) * 1981-06-23 1982-08-10 The Procter & Gamble Company Topical antimicrobial anti-inflammatory compositions
US4369190A (en) * 1981-06-23 1983-01-18 Schulte Thomas L Analgesic composition and use thereof to ameliorate intractable pain
US4476140A (en) * 1983-05-16 1984-10-09 Yale University Composition and method for treatment of glaucoma
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4847290A (en) * 1987-08-17 1989-07-11 Sumner Burstein Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents
US4876276A (en) * 1986-10-24 1989-10-24 Yissum Research Development Co. Of The Hebrew University Of Jerusalem (3S-4S)-7-hydroxy-Δ6 -tetrahydrocannabinols
US4933363A (en) * 1988-08-16 1990-06-12 Elsohly Mahmoud A Method for effecting systemic delivery of delta-9-tetrahydrocannabinol
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB2274588A (en) * 1993-02-02 1994-08-03 Orna Levin Analgesic gel compositions
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
US5389375A (en) * 1993-05-21 1995-02-14 University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -thc
US5635530A (en) * 1991-09-12 1997-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them
US5639460A (en) * 1995-06-07 1997-06-17 Raymond; Hal C. Aqueous plant extract having antiviral activity
US5716638A (en) * 1994-06-22 1998-02-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Composition for applying active substances to or through the skin

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189491A (en) * 1976-12-16 1980-02-19 Cuendet Jean Francois Tetrahydrocannabinol in a method of treating glaucoma
US4343798A (en) * 1981-06-23 1982-08-10 The Procter & Gamble Company Topical antimicrobial anti-inflammatory compositions
US4369190A (en) * 1981-06-23 1983-01-18 Schulte Thomas L Analgesic composition and use thereof to ameliorate intractable pain
US4476140A (en) * 1983-05-16 1984-10-09 Yale University Composition and method for treatment of glaucoma
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4876276A (en) * 1986-10-24 1989-10-24 Yissum Research Development Co. Of The Hebrew University Of Jerusalem (3S-4S)-7-hydroxy-Δ6 -tetrahydrocannabinols
US4847290A (en) * 1987-08-17 1989-07-11 Sumner Burstein Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents
US4933363A (en) * 1988-08-16 1990-06-12 Elsohly Mahmoud A Method for effecting systemic delivery of delta-9-tetrahydrocannabinol
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
US5607933A (en) * 1990-02-26 1997-03-04 Sterling Winthrop Inc. 3-arylcarbonyl-1(C-attached-N-heteryl)-1H-indoles
US5635530A (en) * 1991-09-12 1997-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
GB2274588A (en) * 1993-02-02 1994-08-03 Orna Levin Analgesic gel compositions
US5389375A (en) * 1993-05-21 1995-02-14 University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -thc
US5508037A (en) * 1993-05-21 1996-04-16 The University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -THC
US5716638A (en) * 1994-06-22 1998-02-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Composition for applying active substances to or through the skin
US5639460A (en) * 1995-06-07 1997-06-17 Raymond; Hal C. Aqueous plant extract having antiviral activity

Non-Patent Citations (28)

* Cited by examiner, † Cited by third party
Title
"Developing the Next Generation of Analgesic and Anti-inflammatory Drugs, CT-3", Atlantic Pharmaceuticals, Inc. (www.atlan.com)(1998).
Choy, EH, and DL Scott, "Drug treatment of rheumatic diseases in the 1990s:achievements and future developments", Drugs, vol. 53 (Mar.): pp. 337-348 (1997).
Choy, EH, and DL Scott, Drug treatment of rheumatic diseases in the 1990s:achievements and future developments , Drugs , vol. 53 (Mar.): pp. 337 348 (1997). *
Clark, WC, MN Janal, P. Zeidenberg and G Hahas, "Effects of moderate and high doses of marihuana on thermal pain: sensory decision theory analysis", Journal of Clinical Pharmacology, vol. 21 (Aug.-Sep. suppl): pp. 299S-310S (1981).
Clark, WC, MN Janal, P. Zeidenberg and G Hahas, Effects of moderate and high doses of marihuana on thermal pain: sensory decision theory analysis , Journal of Clinical Pharmacology , vol. 21 (Aug. Sep. suppl): pp. 299S 310S (1981). *
Developing the Next Generation of Analgesic and Anti inflammatory Drugs, CT 3 , Atlantic Pharmaceuticals, Inc. (www.atlan.com)(1998). *
Dow, GJ, FH Myers, W. Stanton and ML Devine, "Serious reacction s to oral DELTA-9 tetrahydrocannabinol in cancer chemotherapy patients", Clinical Pharmacology, vol. 3 (Jan.-Feb.): p. 14 (1984).
Dow, GJ, FH Myers, W. Stanton and ML Devine, Serious reacction s to oral DELTA 9 tetrahydrocannabinol in cancer chemotherapy patients , Clinical Pharmacology , vol. 3 (Jan. Feb.): p. 14 (1984). *
Formukong et al., Analgesic and Antiinflammatory Activityof Constituents of Cannabis Saitiva L., Inflammation 12(4) pp. 361 372, 1988. *
Formukong et al., Analgesic and Antiinflammatory Activityof Constituents of Cannabis-Saitiva L., Inflammation 12(4) pp. 361-372, 1988.
Gill, EW, WDM Paton and RG Pertwee, "Preliminary experiments on the chemistry and pharmacology of cannabis", Nature, vol. 228 (Oct. 10): pp. 134-136 (1970).
Gill, EW, WDM Paton and RG Pertwee, Preliminary experiments on the chemistry and pharmacology of cannabis , Nature , vol. 228 (Oct. 10): pp. 134 136 (1970). *
Goodwin, DW, SY Hill, B. Powell and R. Schwin, "Marihuana: CNS supressant of excitant?", American Journal of Psychiatry, vol. 131 (Mar.): pp. 313-315 (1974).
Goodwin, DW, SY Hill, B. Powell and R. Schwin, Marihuana: CNS supressant of excitant , American Journal of Psychiatry , vol. 131 (Mar.): pp. 313 315 (1974). *
Jochimsen, PR, RL Lawton, K. VerSteeg and R. Noyes, "Effect of benzppyranoperidine, a DELTA-9THC congener, on pain", Clinical Pharmacolog & Therapeutics, vol. 24 (Aug.): pp. 223-227, 1978.
Jochimsen, PR, RL Lawton, K. VerSteeg and R. Noyes, Effect of benzppyranoperidine, a DELTA 9THC congener, on pain , Clinical Pharmacolog & Therapeutics , vol. 24 (Aug.): pp. 223 227, 1978. *
Schwartzfarb, L., M. Needle and M. Chavez Chase, Dose related inhibition of leukocyte migration by marihuana and delta 9 tetrahydroncannabinol (THC) in vitro , Journal of Clinical Pharmacology , vol. 14 (Jan.): pp. 35 40 (1974). *
Schwartzfarb, L., M. Needle and M. Chavez-Chase, "Dose-related inhibition of leukocyte migration by marihuana and delta 9-tetrahydroncannabinol (THC) in vitro", Journal of Clinical Pharmacology, vol. 14 (Jan.): pp. 35-40 (1974).
The Merck Index, An Encyclopedia of Chemical, Drugs and Biologicals, Twelfth Edition, "9349 Tetrahydrocannabinols", Whitehouse Station, New Jersey (1996).
The Merck Index, An Encyclopedia of Chemical, Drugs and Biologicals, Twelfth Edition, 9349 Tetrahydrocannabinols , Whitehouse Station, New Jersey (1996). *
Touitou et al., Transdermal Delivery of Tetrahydrocannabinol, Int. J. Pharm., 42/1 2 pp. 9 15, 1988. *
Touitou et al., Transdermal Delivery of Tetrahydrocannabinol, Int. J. Pharm., 42/1-2 pp. 9-15, 1988.
Weiss, JL, AM Watanabe, L. Lemberger, NR Tamarkin and PV Cardon, "Cardiovascular effects of delta-9 tetrahydrocannabinol in man", Journal of Clinical Pharmacology, vol. 13 (Sep.-Oct.): pp. 671-684 (1972).
Weiss, JL, AM Watanabe, L. Lemberger, NR Tamarkin and PV Cardon, Cardiovascular effects of delta 9 tetrahydrocannabinol in man , Journal of Clinical Pharmacology , vol. 13 (Sep. Oct.): pp. 671 684 (1972). *
Zurier, RB, RG Rossetti, JH Lane, JM Goldber, SA Hunter and SH Burstein, "Dimethylheptyl-THC oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure", Arthritis & Rheumatism, vol. 41 (Jan.): pp. 163-170 (1998).
Zurier, RB, RG Rossetti, JH Lane, JM Goldber, SA Hunter and SH Burstein, Dimethylheptyl THC oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure , Arthritis & Rheumatism , vol. 41 (Jan.): pp. 163 170 (1998). *
Zurier, Robert B., "Pre-Clinical Studies Show CT-3 reduces Chronic and Acute Inflammation and Reduces Destruction of Joints", Arthritis & Rheumatism, (Jan. 1998).
Zurier, Robert B., Pre Clinical Studies Show CT 3 reduces Chronic and Acute Inflammation and Reduces Destruction of Joints , Arthritis & Rheumatism , (Jan. 1998). *

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111377A1 (en) * 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
US8449908B2 (en) 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
US20050266061A1 (en) * 2000-12-22 2005-12-01 Stinchcomb Audra L Transdermal delivery of cannabinoids
US20060147510A1 (en) * 2001-10-25 2006-07-06 Endo Pharmaceuticals, Inc. Method for treating non-neuropathic pain
EP1329265A3 (en) * 2002-01-16 2005-10-12 Giuliano Silvestri Method and device for separating toxic components in plant parts and preparations produced thereby
EP1329265A2 (en) * 2002-01-16 2003-07-23 Giuliano Silvestri Method and device for separating toxic components in plant parts and preparations produced thereby
DE10323497A1 (en) * 2003-02-26 2004-09-23 Musch, Stephan, Dr.med. Well tolerated liquid herbal preparation for reducing and/or adjusting intraocular pressure, containing plant extract(s) having dehydrating, blood purifying, hypotensive and/or spasmolytic action
EP2263667A2 (en) 2005-06-16 2010-12-22 Euro-Celtique S.A. Compositions comprising crystalline trans-(+/-)-delta-9-tetrahydrocannabinol
EP2279735A2 (en) 2005-06-16 2011-02-02 Euro-Celtique S.A. Compositions comprising crystalline trans-(+/-)-delta-9-tetrahydrocannabinol
US20080312583A1 (en) * 2007-06-12 2008-12-18 Oronsky Bryan T Topical composition for treating pain
US9511016B2 (en) 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US20080311217A1 (en) * 2007-06-12 2008-12-18 Oronsky Bryan T Topicial composition for treating pain
US20080311167A1 (en) * 2007-06-12 2008-12-18 Oronsky Bryan T Topical Composition for Treating Pain
US20080311218A1 (en) * 2007-06-12 2008-12-18 Oronsky Bryan T Topical composition for treating pain
US20090036523A1 (en) * 2007-07-30 2009-02-05 Alltranz Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
US8293786B2 (en) 2007-07-30 2012-10-23 Alltranz Inc. Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
WO2009067535A1 (en) * 2007-11-19 2009-05-28 Xvasive, Inc. Topical composition for treating pain
US20090131889A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical composition for treating pain
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
US20090130182A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical compositions for treating pain
US20090247619A1 (en) * 2008-03-06 2009-10-01 University Of Kentucky Cannabinoid-Containing Compositions and Methods for Their Use
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
US20100012118A1 (en) * 2008-07-19 2010-01-21 Markus Storz Medicament dosage for inhaler
WO2010126501A1 (en) * 2009-04-29 2010-11-04 University Of Kentucky Research Foundation Cannabinoid-containing compositions and methods for their use
US20110038915A1 (en) * 2009-08-14 2011-02-17 Eduardo Jose Gonzalez Chewing Gum Formula for Enhancing Psycho-Spirituality
US9936650B2 (en) 2014-09-09 2018-04-10 Podgrow, LLC Secure and externally controllable growing enclosure
US9375417B2 (en) 2014-12-04 2016-06-28 Mary's Medicinals LLC Transdermal cannabinoid formulations
US10028904B2 (en) 2014-12-04 2018-07-24 Wisconsin Alumni Research Foundation Transdermal cannabinoid formulations
US10675240B2 (en) 2014-12-04 2020-06-09 Mm Technology Holdings, Llc Transdermal cannabinoid formulations
US10456357B2 (en) * 2016-07-28 2019-10-29 Allen Greenspoon Orally administrable formulation
AU2020257071B2 (en) * 2016-07-28 2021-03-25 Allen Greenspoon Novel orally adminstrable formulation
US11147777B1 (en) 2017-06-16 2021-10-19 Charlotte's Web, Inc. Methods and formulations for efficacious pain relief by transdermal delivery of cannabidiol
WO2019016814A1 (en) 2017-07-20 2019-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical film compositions for delivery of lipophilic compounds into and/or across the skin

Similar Documents

Publication Publication Date Title
US6132762A (en) Transcutaneous application of marijuana
CA1332570C (en) Method for reducing skin irritation associated with drug/penetration enhancer compositions
US5503825A (en) Lip balm composition
US4725609A (en) Method of promoting healing
EP0954278B1 (en) Pharmaceutical compositions containing kukui nut oil
EP0087062B1 (en) Pharmaceutical composition containing ibuprofen for external application, and method of preparing the same
US20080170997A1 (en) Compositions for the treatment and prevention of cancer
US6391323B1 (en) Composition for the treatment of burns, sunburns, abrasions, ulcers and cutaneous irritation
CN108056931A (en) A kind of acne eliminating cream and preparation method thereof
US8383166B2 (en) Stable hydrophobic topical herbal formulationn
CN109833431A (en) A kind of bacteriostatic gel and preparation method thereof
JPH04502145A (en) Terpene ozonides and their medical uses
CN101496833B (en) Liquid external preparation for preparing total alkaloids in nux vomica
US11229610B2 (en) Cannabinoid and menthol gel compositions, patches and methods
WO2021257027A1 (en) An effective composition in healing wounds
US20080193552A1 (en) Topical medicament for skin injuries and disorders
EP0348215A2 (en) Novel cosmetic and paramedicinal compositions
US5576005A (en) Effectiveness of wart removal by compositions including propolis
CN111544564B (en) Ointment for treating infant diaper dermatitis and preparation method thereof
JP2013508389A (en) Therapeutic composition
CN1491647A (en) Composition for percutaneous treating impotence and female sexual cold and preventing sextual disease
CN106806713A (en) A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil and preparation method thereof
JPH0568448B2 (en)
TWI284531B (en) External preparation for skin diseases containing nitroimidazole
JP2506216B2 (en) Anti-inflammatory analgesic external preparation

Legal Events

Date Code Title Description
FEPP Fee payment procedure

Free format text: ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: SMAL); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY

AS Assignment

Owner name: RED CHIP COMPANY LTD., (A BRITISH VIRGIN ISLANDS C

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INTERSIL CORPORATION, (A DELAWARE CORPORATION);REEL/FRAME:011044/0101

Effective date: 20000720

STCF Information on status: patent grant

Free format text: PATENTED CASE

REMI Maintenance fee reminder mailed
FPAY Fee payment

Year of fee payment: 4

SULP Surcharge for late payment
REMI Maintenance fee reminder mailed
FPAY Fee payment

Year of fee payment: 8

SULP Surcharge for late payment

Year of fee payment: 7

FPAY Fee payment

Year of fee payment: 12