[Klion D - possibilities of prophylaxis and treatment during pregnancy]

Akush Ginekol (Sofiia). 2001;40(4):42-4.
[Article in Bulgarian]

Abstract

Objective: To evaluated and dilated possibilities of prophylaxis and treatment of agent Klioton D in pregnant women.

Material and methods: 164 women were evaluated for 1.5 year period between 12 and 40 gest. week. The first group of prophylactic usage was consisted of 118 women, divided in two groups: prophylaxis before cerclage--33 women, between 12 and 20 gest. week, and prophylaxis before delivery--85 cases. The second group was therapeutic usage in 46 women between 16 and 34 gest. week.

Results: Microbiologically superiority of unspecific bacterial agents was proved, mixed bacterial aerobic-anaerobic flora was dominated. More common bacterial vaginosis and candidosis were noted. In therapeutic group 80% were cured. The rate of subjective complaints in two groups was evaluated. Complications after delivery were 0.04%. Complications after cerclage weren't noted.

Conclusion: Microbiological type find in pregnant women and good prophylactic and the therapeutic results make Klion D as appropriate therapeutic agent before cerclage, delivery, in imminent abortions and premature labors.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract

MeSH terms

  • Administration, Intravaginal
  • Animals
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use*
  • Cerclage, Cervical
  • Drug Therapy, Combination
  • Female
  • Humans
  • Metronidazole / administration & dosage
  • Metronidazole / adverse effects
  • Metronidazole / therapeutic use*
  • Miconazole / administration & dosage
  • Miconazole / adverse effects
  • Miconazole / therapeutic use*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Vaginal Diseases / drug therapy

Substances

  • Anti-Infective Agents
  • Metronidazole
  • Miconazole