Abstract
We describe 3 cases of acute gastroenteritis in healthy infants after vaccination with RotaTeq, shedding a G1P[8] human-bovine double reassortant rotavirus in stools. Such a double reassortant virus appears stable in vitro and may explain diarrheal symptoms in a small percentage of RotaTeq recipients, and might also be transmitted to contacts in the environment.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Feces / virology
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Female
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Gastroenteritis / diagnosis
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Gastroenteritis / virology*
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Humans
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Infant
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Male
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Prospective Studies
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Reassortant Viruses / classification
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Reassortant Viruses / genetics*
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Reassortant Viruses / isolation & purification
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Rotavirus / classification
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Rotavirus / genetics*
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Rotavirus / isolation & purification
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Rotavirus Infections / diagnosis
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Rotavirus Infections / virology*
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Rotavirus Vaccines / adverse effects*
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Vaccines, Attenuated / adverse effects
Substances
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RotaTeq
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Rotavirus Vaccines
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Vaccines, Attenuated