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A review of recent findings and innovative approaches for treating scalp disorders.
By: Nava Dayan
April 1, 2016
The scalp is part of the integumentary protecting system of the human head, a distinctive skin area with relatively high follicular density and sebum production and secretion. When covered with hair, the scalp is a protected environment that is a welcome setting to the inhabitation of microorganism population different from that present in other body areas. Biota imbalance on the scalp can give rise to infections associated with a variety of clinically manifested conditions. In recent years, efforts have been made to better identify scalp biota population and differentiate between a healthy and disease afflicted scalp; some are detailed in this article. However, the connection between biota population, and its activity and effect on scalp skin innate immunity is largely unclear. To further understand the interplay between the scalp microbiome and its effect on skin cells, a combination of biome and omics research is to be employed in which biota’s activity is considered and drawn to map innate immunity components. For such projects, teamwork between microbiologists and omic biologists is essential. The most common scalp conditions are dandruff (DF) and seborrheic dermatitis (SD). They share cause and characteristics, with DF considered mild and SD being the more severe condition. Knowledge that exemplify the importance of biota-innate immunity axis investigation as related to these conditions lies in the fact that at the cellular biochemical level SD is associated with attenuation of T cells activity and hence provides an indication of decreased immune responsiveness as well as activation of the alternative complement pathway. However it is not clear if the source of such reduced immunity is systemic and reflects overall health or is confined to the skin; or a combination thereof. If the disorder stems from overall health condition; topical treatment may provide limited results and a more comprehensive approach should be exercised. When compared to skin in other body areas scalp skin is:
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